| Abstract No.: | B-C2093 |
| Country: | Canada |
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| Title: | GENETIC ASSOCIATION STUDY OF RGS4 POLYMORPHISMS WITH SCHIZOPHRENIA |
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| Authors/Affiliations: | 1 Renan Souza*; 2 Marco Romano-Silva; 1 James Kennedy;
1 CAMH, Toronto, ON, Canada; 2 UFMG, Belo Horizonte, Brazil
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| Content: | The study of schizophrenia genetics has confirmed the importance of genes in etiology, but has not so far identified the relationship between observed genetic risks and specific DNA variants, protein alterations or biological processes. Gene expression analyses of postmortem cerebral cortex suggest that transcription of the regulator of G-protein signaling 4 (RGS4) is decreased in a diagnosis-specific manner in subjects with schizophrenia. To evaluate the possible role of RGS4 in the pathogenesis of schizophrenia, we conducted genetic association study. We compared allelic; genotypic and haplotypic frequencies of rs10759, rs10799897, rs2661319 and rs2842030 in 219 matched case-control subjects. No significant association with schizophrenia was found for any evaluated marker in our sample. Our results suggest that the RGS4 may not affect susceptibility to develop schizophrenia. |
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