| Abstract No.: | 114 |
| Country: | Canada |
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| Title: | Neuronal Correlates of Functional MRI Signals in Monkey Visual Cortex |
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| Authors/Affiliations: | Amir Shmuel,
Montreal Neurological Institute, McConnel Brain Imaging Centre
Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
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| Content: | Recent advances in imaging sciences have provided platforms that make it possible to investigate how human brain activity correlates with cognition. The majority of functional brain imaging studies in humans relies on functional MRI (fMRI) and on imaging the Blood Oxygenation Level-Dependent (BOLD) signal in particular. FMRI relies on metabolic and hemodynamic changes to infer underlying local changes in neuronal activity. The fMRI signal may therefore be considered only an indirect measure of neuronal activity. Understanding how metabolic and hemodynamic signals are derived from the underlying neuronal activity is therefore essential for using fMRI as a tool to study brain function.
This presentation will briefly review recent studies that established a link between increases in neuronal activity and localized increases in cerebral blood flow and BOLD signals. It will then focus on decreases in fMRI signals relative to baseline, showing that these are associated with decreases in neuronal activity. The presentation will be concluded with a discussion on the neuronal correlates of spontaneous fluctuations in fMRI signals in the resting state, in the absence of any stimulus or task.
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