| Abstract No.: | C-A3001 |
| Country: | Canada |
| | |
| Title: | A NOVEL MUTATION AFFECTING NEURONAL MIGRATION IN DROSOPHILA MELANOGASTER |
| | |
| Authors/Affiliations: | 1 Scott Cameron*; 1 Yong Rao;
1 McGill Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Mcgill University Health Centre, Montreal, QC, Canada
|
| | |
| Content: | The developing Drosophila eye undergoes a well stereotyped process of morphogenesis in which the cell bodies of the newly differentiated photoreceptor cells (R-cells) undergo basal-to-apical migration in the developing retina, which is analogous to the migration of cortical neurons in the developing human brain. Importantly, the fly homologues of several genes (e.g. Lissencephaly and Disabled) whose mutations caused defects in mammalian cortical neuronal migration, have also been shown to be required for R-cell migration. Thus, the study of R-cell migration in the fly eye may provide novel and important insights into the general mechanism regulating neuronal migration during neural development. Our studies have uncovered a novel mutation that disrupts the positioning of R-cell nuclei. We are currently investigating the molecular identity of this gene by deletion mapping and the results will be presented. |
| | |
| Back |
|
